Biosynthesis and Structural Properties of Sulfur Nanoparticles Using Proteus mirabilis Extract and its Effect on Pathogenic Bacteria
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Abstract
This research focuses on exploring the therapeutic potential of sulfur nanoparticles (sulfur NPs) synthesized from Proteus mirabilis (P. mirabilis) extract against Staphylococcus aureus )S. aureus), a pathogen implicated in skin infections. The study identified significant inhibitory effects of these nanoparticles on biofilm-producing and multidrug-resistant S. aureus isolates (A5, A8, A9, A11, and A29), with minimum inhibitory concentrations ranging from 16 to 32 µg/mL. While the study found no statistically significant differences in inhibition rates across various nanoparticle concentrations (p=0.842), there was a notable increase in anti-biofilm activity with higher concentrations (p<0.05). For instance, at 1024 µg/mL, the inhibition rate was approximately 93.1%, compared to 5.2% at 2 µg/mL (p=0.0001). These findings underscore the promising antimicrobial efficacy of sulfur NPs derived from P. mirabilis in combating drug-resistant S. aureus infections and biofilm formation commonly associated with dermatitis.
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