Determination Of Mtronidazole In Pharmaceutical Preparations

Abstract

     Due to the selective toxicity to anaerobic bacteria and protozoarium, metronidazole (MTZ) has been found to be clinically useful in a variety of anaerobic and  protozoarium infection, particularty Trichomonas Vaginalis and Amoebic Dysentery ^[1]. It can kill or inhibit the majority of anaerobic bacteria when the metronidazole concentration in serum is in the range from 2 to 8 μg/ml ^[2]. Therefore, the determination of trace levels of MTZ is very necessary in clinics.