Study the effect of oxazepine derivatives of alkaline phosphatase in normal persons sera

Abstract

The inhibitory effect of new organic compound which is derivative of oxazepine on the activity of alkaline phosphatase in normal persons serum have been studied

This compound was :

2 ( p-toyl) 3 – (2- traizole ) -2,3    dihydro  {1,3} – oxazepine – 4,7  dione   

The percentage of inhibition caused by oxazepine derivative was to be arranged between 22.5 – 69 %

The result from line weaver – burk  plot indicated that the inhibition was competitive which maximum velocity vmaxwhile Micheal menten constant Km is decreased in presence of inhibitor 9 m mol/L while the value of Km  without inhibitor

is 10 m mol/L .

synthesis new 1,3 oxazepine  4-7 dion derivatives which are expected to have biological activity which are most active anticonvulsant.