Study of Cytopathological effect of B-hemolysin of Aeromonas hydrophil

Abstract

In this study, the local isolate of genus Aeromonas hydrophila which isolated from local fresh water was used,. This bacterium was investigated to produce B-hemolysin, the haemolytic activity of hemolysin against different RBCs sources  shown human RBC s was optimum  for hemolysis with value 65 unit, while sheep and rabbit RBCs hemolysis were 55, 52 unit respectively. The Histopathological effects for hemolysin and bacterial suspension were study, it was found that the hemolysin more active on kidney tissue of injected mice  and caused many changes comparatively with bacterial suspension  include atrophy of renal glomerulus, degeneration of nucleus , vaculation of cytoplasm , PMNs filtration and few hemorrhage in kidney tissue.