Synthesis, spectral characterization and biological studies of the ligand type N2O4 Schiff- bases and their (Fe (II), Zn (II), Cd (II) and Hg (II)) complexes.

Abstract

This study aimed to synthesis and characterize hexadentate Schiff's base ligand with the general structure (H₂L) containing nitrogen and oxygen donor atoms type (N₂O₄).The ligand (N,N)-bis-(salicylidine)-1,2-bis-(o-aminophenoxy) ethane (H₂L) was prepared from the reaction of o-aminophenol with salicylaldehyde in an acidic medium and the precursor 2-(2-hydroxybenzylieneamino) phenol was obtained, this precursor was reacted with dichloroethane in alkali medium to obtain the ligand (H₂L).The prepared ligand (H₂L) is characterized by FT-IR,UV-Vis,¹H-NMR spectra and. The ligand was reacted with some metal ions under reflux in methanol with (1:1) ratio gave complexes of the general formula [M (L)], Where: M^II= Fe, Zn , Cd and Hg. These complexes were characterized by atomic absorption, chloride content, I.R, U.V-Vis spectra, molar conductivity, HPLC, melting point, and biological activity were tested for some complexes of this ligand .The molar conductance showed that, all complexes are non-electrolyte. According to all these measurements . The proposed structures for (H₂L) complexes were an tetrahedral geometry for Fe^II , Zn ^II , Cd^II  and Hg^II .     

Keywords: Schiff-base ligand; (N,N)-bis-(salicylidine)-1,2-bis-(o-aminophenoxy) ethane; structural and biological studies