Synthesis of Some New Schiff Bases and Reaction with Urea & Thiourea Derivatives from 2-Amino -1,3,4-thiadiazole-5-thiol

Abstract

In this paper new Schiff bases and tetrazole derivatives of 2-Amino-1,3,4-thiadiazole- 5-thiol have been prepared.2-Amino-1,3,4-thiadiazole-5-thiol was prepared by the reaction  of  thiosemicarbazide  with  carbon  disulfide  in  alcoholic  sodium  carbonate solution .The new Schiff bases derivatives [2_5] were prepared by condensation of aldehyde group with 2-Amino-1,3,4-thiadiazole-5-thiol (P-Nitrobenzeldehyde ,M- Nitrobenzeldehyde, P-Hydroxybenzeldehyde, , 4-Hydroxy 3-Methoxy benzeldehyde)  . The resulting Shiffbase were

Reaction with acetic anhydride [6-9] and this derivatives reaction with  urea and thiourea  intetrahydrofuran{10-17}.

All new synthesized derivatives were identified by their melting points, and  FT-IR,U.V  spectra. Some products were identified in elemental  analysis and Chledal analysis .They  have  long  been  known  to  possess hypnotics activities and it is hoped that our compounds would do so.