Synthesis and characterization of some new heterocyclic compounds

Abstract

This work includes preparing of some new derivatives of pyrimidine ,pyrazolidine, and isoxazolidine  from the reaction between tetraethyl  2,2' -(1E,1E' )- biphenyl ll-4, 4' -diylbis(diazene-1,2-diyl)dimalonate(1) and ammonia derivatives in dry ethanol to obtain the six membered hetero rings: 5,5'-(1E,1E') biphenyl-4,4'-diylbis (diazo-1,2-diyl)bis(2-mercaptopyrimidine-4,6-diol)(2) ; 5,5'-(1E,1E' ) biphenyl-4,4'-diylbis(diazo-1,2-diyl)dipyrimidine-2,4,6-triol(3);5,5'-(1E,1E')-biphenyl-4,4'-diylbis (diazo-1,2-diyl)bis(2-aminopyridine-4,6-diol)(4); and five membered  hetero ring: 4,4' -(1E,1E')-biphenyl-4,4'-diylbis(diazene-1,2-diyl)dipyrazolidine-3,5-dione(5);4,4'-(1E , 1E')-biphenyl-4,4'-diylbis(diazene-1,2-diyl)bis(1-phenylpyrazolidine-3,5-dione)(6); 4,4'-(1E,1E')-biphenyl-4,4'-diylbis (diazene-1,2-diyl)diisoxazolidine-3,5-dione)(7).

    The prepared compounds were characterized by spectral methods FT-IR ,¹H-NMR and measurement of some of its physical properties ; and the reaction was followed by TLC.