Synthesis and Characterization of some biologically active transition metal complexes for a ligand derived from dimedone with mixed ligands.

Abstract

The aim of the work is synthesis and characterization of bidentate ligand
[3-(3-acetylphenylamino)-5,5-dimethylcyclohex-3-enone][HL], from the
reaction of dimedone with 3-amino acetophenone to produce the ligand
[HL], the reaction was carried out in dry benzene as a solvent under reflux.
The prepared ligand [HL] was characterized by FT-IR, UV-Vis
spectroscopy, 'H, 8C-NMR spectra, Mass spectra, (C.H.N) and melting
point. The mixed ligand complexes were prepared from ligand [HL] was
used as a primary ligand while 8-hydroxy quinoline [HQ] was used as a
secondary ligand with metal ion M(IT).Where M(IT) = (Mn ,Co ,Ni ,Cu ,Zn
,Cd and Pd) at reflux ,using ethanol as a solvent, KOH as a base.
Complexes of the composition [M(L)(Q)] with (1:1:1) molar ratio were
prepared . All the complexes were characterized by spectroscopic methods
(FT-IR, UV-Vis spectroscopy) along with elemental analysis (A.A),
chloride content and melting point measurements were carried out, together
with conductivity and magnetic susceptibility. These measurements showed
tetrahedral geometry around (Mn", Col, Ni, Cu", Zn! and Cd") ions and
square planner around (Pd") ion. The biological activity of the ligands
[HL],[HQ] ] and complexes (MLQ): were studied using inhibition method.