Study the action of pycnogenol on glucose and lipid profile in type -2- diabetic patients

Abstract

Pycnogenol  pinus pinaster Ait ( a water extract of polyphenolic compounds ) was extracted from Iraqi pine bark and analyzed using high performance liquid chromotography (HPLC) coupled to ultra violet UV detection that was recorded at (254 nm).

           Pycnogenol action on some biochemical parameters (glucose , total cholesterol (TC) , triacylglycerol (TG) , high density lipoproteins (HDL) ,low density lipoproteins (LDL) , very low density lipoproteins (VLDL) )level was determined in (30) type -2- diabetic patients who treated with capsules (500 mg) of pycnogenol three times daily to examine the reactive role of pycnogenol against oxidative stress.The above biochemical parameters were measured in plasma before treatment with pycnogenol and after (1 week) , (2 weeks) and (3 weeks) of treatment with this polyphenolic extract.

           Our results have shown that  glucose level was increased relatively for diabetic patients compared with control group (p<0.001) but after treatment with pycnogenol , glucose level would be decreased relatively (p<0.001) after (1 week) , (p<0.001) after (2 weeks) and (p<0.05) after (3 weeks) of treatment with pycnogenol.Total cholesterol (TC) level increased relatively for diabetic patients compared with control group (p<0.001) , but after treatment with this reactive extract  (TC) level  decreased relatively (p<0.001) after (1 week) , (p<0.001) after (2 weeks) and (p<0.01) after (3 weeks) of treatment with pycnogenol.Triacylglycerol (TG) level was  increased relatively for diabetic patients compared with control group (p<0.001) , but after treatment with this antioxidant  extract  (TG) level decreased relatively (p<0.001) after (1 week) , (p<0.001) after (2 weeks) and (p<0.01) after (3 weeks) of treatment with pycnogenol.High density lipoproteins (HDL) level was decreased relatively for diabetic patients compared with control group (p<0.001) , but after treatment with pycnogenol (HDL) level increased relatively (p<0.01) after (1 week) , (p<0.01) after (2 weeks) and (p<0.05) after (3 weeks) of treatment with pycnogenol.Low density lipoproteins (LDL) level increased relatively for diabetic patients compared with control group (p<0.001) , but after treatment with  pycnogenol , (LDL) level decreased relatively (p<0.001) after (1 week) , (p<0.001) after (2 weeks) and (p<0.01) after (3 weeks) of treatment with pycnogenol. Very low density lipoproteins (VLDL) level increased relatively for diabetic patients compared with control group (p<0.001) , but after treatment with  pycnogenol , (VLDL) level decreased relatively (p<0.001) after (1 week) , (p<0.001) after (2 weeks) and (p<0.01) after (3 weeks) of treatment with pycnogenol.