The Association Between Certain Immunological Markers And Clinical Manifestation Of SLE In Iraqi Arab Patients

Abstract

The present study was conduction to have a clearer integrative idea

on the impact of immunological abnormalities including a set of auto

antibodies on the clinical expression of lupus among Iraqi Arab patients,

compared with a normal population matched in ethnic background. A

total of (39) well diagnosed patients with lupus attending the

rheumatology clinic of medical city in Baghdad (from Jun – 2005 to

October – 2006) have been studied compared with (40) normal

individuals of a blood bank donors as a general control.

Indirect immunofluorescent technique was used to assess the

prevalence of antinuclear antibody among subjects group, while other

auto antibodies including anti – ds DNA, anti – Sm, anti – Ro, anti – La,

anti – Sm RNP, and anti- cardiolipin antibodies were detected with

enzyme immuno assay (EIA) and rheumatoid factor with latex

agglutination.

Patient's group reported prevalence of all the eight sero

immunological abnormalities in a statistically significant way, compared

to general control. The risk for having a positive immunological marker

for cases (represented by odds ratio) ranged between (7.5) for

rheumatoid factor to (61.2) for antinuclear antibodies. Besides, selected

auto antibodies were significantly associated with particular

manifestation. Patients testing positive for rheumatoid factor had a

significant risk of having malar rush (OR = 11.0 , P < 0.05) and those

how had positive results for anti – ds DNA and anti – Sm antibodies had a

significant risk of having renal involvement (OR = 4.7 and 4.3

respectively , P < 0.05) , while having anti – Ro antibodies decrease the

risk of developing arthropathy (OR=0.2, P < 0.05). Nonetheless,