Synthesis of N-Substituted 3-Chloro- 2-azetidinones for 2, 4-diamino-6- hydroxy pyrimidin

Abstract

This search involved synthesis of several new N-Substituted -3-chloro-
2-azetidinones which were known as a high medicinal effectiveness for 2,
4-Diamino-6-hydroxy pyrimidin in two steps. The first step included
preparation Shiff bases (1-6) by condensation of 2, 4-Diamino-6-hydroxy
pyrimidin with many substituted aldehydes(4-hydroxy benzaldehyde, 2-
bromobenzaldehyde, 4-dimethyl amino benzaldehyde, = 4-nitro
benzaldehyde, salicylaldehyde, 4-chlorobenzaldehyde), then the second
step included, preparation new six azetidinones compounds (7-12) by
reaction of chloroacetylchloride with the prepared Schiff bases in the first
step in the presence of triethylamine. The structures of synthesized
compounds were- characterized by physical properties (FT-IR, UV and
some of them by 'H-NMR, C_NMR spectroscopy) were recorded.