The interaction between Hyperglycaemia and Rheumatoid Factor in Iraqi Diabetic Patients with type I

الملخص

Diabetes mellitus (DM) is a clinical disorder characterized by hyperglycemia caused by a lack of insulin, when an individual's body can't make enough insulin or utilize insulin to create energy from glucose. Many kinds of diabetes are perceived: type 1 (T1DM) and type 2 (T2DM), previously named "insulin"-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM).

      Rheumatoid factor has a positive indicative value on diagnosis and has an association with the prognosis of rheumatoid arthritis. In some instances, RF was found in the serum of patients with different illnesses including DM, because of the presence of pro-inflammatory cytokines like TNF-α which assume a significant part in the autoimmune system, and chronic inflammation like rheumatoid arthritis (RA). This study aimed to find the interactions between        T1DM & RA regarding rheumatoid factors (RF) and hyperglycemia in patient groups.  One hundred patients with type 1 diabetes mellitus were included in this study from patients attending the National Diabetes Center from 2023 to 2024 and twenty healthy non-diabetic, non-arthritic volunteers as a control group, the age range of all participants were within (30-80) years.  From one hundred T1DM patients (fifty-one females and forty-nine males), twelve of them (12%) had positive RF compared with control groups P=0.01 with female dominance 7(58.3%) compared to males 5(41.7%). moreover, the majority of diabetic patients were within the age group (41-50) to male and (51-60) to female respectively with the most elevated level of glucose blood (20.7mmol/L).   The results of the current study demonstrated that the highest proportion of patients with T1DM and RF positive values were in the age category (51-60) years, with significantly different values (P = 0. 0l). We can conclude from this study that there is a correlation between hyperglycemia in type 1 diabetic patients and rheumatoid factor, especially in older females than older males