Synthesis and Characterization of Some New Heterocyclic Compounds Via Unsaturated Ketone with Evaluating of Their biological Activity

الملخص

This work includes preparing of some new derivatives of pyrimidine ,
pyrazole , and isoxazole from the reaction between
 
benzylideneacetophenone (chalcone) (1) and hydrazine derivatives in the
presence of sodium acetate and dry acetone to obtain heterocyclic
compounds (2-6).
 
Reaction of (2) with different substituted benzaldehydes in absolute
ethanol and drops of glacial acetic acid gave Schiff bases derivatives (8-
10) respectively. Schiff bases (8-10) were reacted with sodium azide in
THF to give tetrazole derivatives (11-13). Reaction of (2) with sodium
nitrate and concentrated hydrochloric acid , then with phenol gave diazo
compound (7).
 
The prepared compounds were diagnosed mediated FT.IR,'H-
NMR,UV/Vis spectra, melting points were recorded and the purity was
checked through TLC technique. The biological effectiveness were
measured for some prepared compounds.