A study of the effect of some antifungals and plant extracts on the growth of some dermatophytes that cause ringworm diseases [Ring worm]

Abstract

Minimal Inhibititory Concentration (MIC) and Minimal Fungicidal  Concentration (MFC) were tested using cultural mixing method for three antifungal :- Fluconazole (FLU) , Itraconazole  )ITZ) and Griseoflvin (GRI), against dermatophytes isolates(Trichophyton. mentagrophytes  ,Trichophyton verrcossum  , Trichophyton rubrum  and Trichophyton tonsurans. Results showed that all species of Trichophyton  showed  sensitivity  against (FLU) and the rate of  (MIC) for (FLU) ,  )ITZ) and ( GRI) 5.13 µg /ml , 0.46 µg /ml and 8.35 µg /ml , respectively , while (MFC)  9.20 µg /ml , 0.89  µg /ml  and 16.92   µg /ml respectively .

        Peel  extract  of  Punica granatum and seed extract  of Carica  papaya  were prepared using water and ethanol . The inhibitory effect of extracts against the growth of T. mentagrophytes were depended on extract kind and extract concentration .

      The peel of  Punica granatum  alcohol extract showed the highest inhibition  activity  with a rate of  100%  in  both  concentration (5% and 7.5%) , while  the  aqueous extract with concentration  7.5%  showed the highest inhibition  activity  with a rate of 100% . The seed of papaya  alcohol extract showed the highest inhibition  activity  with a rate of  100%  in  both  concentration (5% and 7.5%) , whereas the  aqueous extract with concentration  7.5%  showed the highest inhibition  activity  with a rate 70.59 % .