Distribution of blood leukocytes and screening frequency in patients with type-1 diabetes

Abstract

Blood group antigens, are associated with autoimmune diseases .studies emphasized on lewis blood groups The present study concentrated on finding the frequency distribution of Lewis blood groups in type-1 Diabetes compared to the distribution in healthy controls.

Fiftynine diabetic female samples as well as 5o male diabetic sampleand 25 sample of male and female controls were included.The findings indicated that lea molecule has arole in disease  susceptibility. Its percentage approach 32% in female patients compared to 12% in healthy controls (p=6.4x 10^-4). On the other hand however, lea^-b⁺ group gave  23% in diabetic females compared to 64% in healthy females (p= 4.98 x10^-9). Lea ⁺ b ⁺ group gave 17% in diabetic females and 16% in healthy females (p=0.46).Interestingly however, lea ^– b^- groups was represented at 23% in females verus 8% in healthy females (p=1.2x 10^-3). In males the results of the frequenecies could be summarized as follows :Lea ⁺ b^-  20% in diabetics vs 24% in controls p=(0.239).Lea^- b⁺: 32% in diabetics  vs 40% in controls.      P=(= 0.31).Lea⁺b⁺: 10% in diabetics vs 16% in controls .P= (0.462).Lea^- b^- : 13% in diabetics vs 20% in controls.P=(0.31).

The role of secretion(se gene role) in diabetes was investigated also, particularly in lea group and the findings were as follows: secretors female :50% in diabetics vs 33.3% in controls.(p=0.015).

None secretors: 12.5% in diabetics vs 40% incontrols (p=6.37x10^-6).

In addition to that the role of secretion was seen in lea^-b^- group as well.

             S ecretor diabetics female, showed 62.5%  . There was no arailable sample in controls.

A statistically siqnificant frequency differences was seen in non secretors diabti, females compared to controls (37.5% in diabetics vs 100% in controls ,p=8.8 x 10^-22).

In Males the results of secretions reparted a sisnifiant  difference in nonsecretors(83.3%). In diabetics vs 20% controls ( p= 4.94 x 10-3)