Influence of pH, light and temperature on the stability of Amoxicillin and Triprolidine HCI.

Abstract

The stability of two drugs Amoxicillin and Triprolidine . HCl was
studied in aqueous solution . The results show that Amoxicillin was stable in
PH range (2-8), while it decomposed at pH more than (6) . The same results
have been shown when the solution temperature was varied between 25-
100C° , the decomposition occurred at a temperature above 60C° . When
Amoxicillin exposed to UV light in presence of O, gas , it was unstable , but
was relatively stable in the absence of O> gas . Triprolidine HCl was stable
under the same above condition and factors .
UV- Visible spectrometer was used to follow the spectrum of two drugs.