Levels of Liver Enzymes and Some Changes in Renal Functions in Iraqi Hypothyroid Patients Women

Abstract

     The present study aimed to investigate physiological disorders in some liver and kidney functions in hypothyroid Iraqi women .The   study was carried on 120 subjects in the Specialist Center of Endocrine and Diabetic diseases at Rusafa region, near AL-Kindey Hospital . That study began on 20/10/2013  to 25/1/2014

      The subjects were divided into 4 groups (control, euthyroid ,subclinical and overt hypothyroid).Each group included 30 females ,their ages ranged (39.45 ±1.79) years.

      The results showed a significant(P˂ 0.05) increase in the level of  TSH in subclinical (18.23 ± 2.34mu/l) and overt hypothyroid patients
(41.37 ± 3.75 mu/l) in comparison with control (2.09 ± 0.23mu/l) and euthyroid groups (2.89 ± 0.20mu/l). The levels of T4 and T3 were within the normal limits in control (79.73 ± 2.11 nmol/L);(1.70 ± 0.07nmol/L),euthyroid (87.10 ± 2.16 nmol/L) ;  (1.58 ± 0.05nmol/L) and subclinical (77.76 ± 2.31nmol/L) ; (1.52 ± 0.08 nmol/L)respectively. While overt hypothyroid group showed a significant (P˂0.05) decrease in T4 level (46.36 ± 2.32 nmol/L) with normal T3(1.30 ± 0.11 nmol/L).

      The changes in liver function tests in overt hypothyroid group showed a significant (P˂0.05) increase in the levels of SGOT (23.05 ± 2.67U/L),SGPT(21.89 ± 2.35 U/L) and ALP(99.98 ± 7.47 U/L) in comparison with SGOT in control (8.80 ± 0.88 U/L) , euthyroid (11.36 ± 0.85 U/L) and subclinical (11.88 ± 1.42 U/L) and SGPT in control (13.46 ± 0.75 U/L) euthyroid (10.93 ± 1.03 U/L), and subclinical (14.08 ± 1.87 U/L) and  in the level of ALP in control(50.27 ± 2.65 U/L),euthyroid (65.27 ± 2.87 U/L) and subclinical(71.58 ± 4.90 U/L) respectively.

     Total serum protein(7.49 ± 0.16 g/dl) and bilirubin (1.23 ± 0.11 mg/dl)  were increased significantly (P˂ 0.05) in overt hypothyroid patients in comparable with control (6.82 ± 0.04 gm/dl) ; (0.613 ± 0.04 mg/dl),euthyroid(6.93 ± 0.07gm/dl) ;(0.653 ±0.04 mg/dl),  and subclinical (6.91 ± 0.08 gm/dl);(0.883 ± 0.08 mg/dl) respectively.

       Creatinine level was increased significantly (P˂0.05) in subclinical and overt hypothyroid groups (1.07 ± 0.07mg/dl);(1.26 ± 0.06mg/dl), in comparable with control and euthyroid groups (0.846 ± 0.03),(0.836 ± 0.02) respectively.The level of uric acid was increased significantly (P˂0.05) in the overt group(7.11 ± 0.11mg/dl) in comparable with control,euthyroid and subclinical (3.78 ± 0.18mg/dl),(3.66 ± 0.16mg/dl),(4.42 ± 0.28mg/dl) respectively.

     We concluded from this study that the overt hypothyroidism had effected the liver function tests by increasing liver enzymes SGOT,SGPT,and ALP . Also we found that total plasma protein and bilirubin levels were increased  in overt hypothyroid group.The renal function test showed an increase in the levels of creatinine in subclinical and overt hypothyroid groups while uric acid increased  in overt hypothyroid .

      Euthyroid  group showed  normal levels for the above studied parameters which means that the levels of these parameters returned to the normal values in treated hypothyroid group (euthyroid patients) with  Levothroxine –L at a dose 50mg or 100 mg orally.